Rao - Developmental Neurobiology 4e (Kluwer, Neuroscience
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DEVELOPMENTAL
NEUROBIOLOGY
Fourth Edition
 DEVELOPMENTAL
NEUROBIOLOGY
Fourth Edition
Edited by
MAHENDRA S. RAO
National Institute on Aging
Bethesda, MD
and
MARCUS JACOBSON
â€
University of Utah
Salt Lake City, UT
â€
Deceased
Kluwer Academic / Plenum Publishers
New York, Boston, Dordrecht, London, Moscow
 Library of Congress Cataloging-in-Publication Data
ISBN 0-306-48330-0
© 2005 by Kluwer Academic / Plenum Publishers, New York
233 Spring Street, New York, New York 10013
10987654321
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Printed in Singapore
Marcus Jacobson
Marcus Jacobson, a prominent scholar of developmental neuro-
biology, died of cancer at his home in Torrey, Utah in November,
2001; he was 71.
Jacobson was born in South Africa and finished medical
training at the University of Cape Town. He then completed gradu-
ate study at Edinburgh University, receiving a Ph.D. in 1960 for a
dissertation concerning specificity of synaptic connections in the
Xenopus
retinotectal system. Over the next two decades, Jacobson
exploited the experimental opportunities provided by this prepara-
tion to become one of the best-known researchers of nervous sys-
tem development, first at Purdue University then at Johns Hopkins
University and the University of Miami (Hunt and Jacobson, 1974).
In 1977, Jacobson moved to the University of Utah to become
chairman of the Department of Neurobiology & Anatomy; he
expanded the department and refocused its research on develop-
mental neurobiology, a field in which it maintains a strong reputa-
tion. Shortly after moving to Utah, Jacobson began using single-cell
injection techniques and lineage tracing in
Xenopus
to study early
patterning of the nervous system (Jacobson, 1985).
In 1970, Jacobson published
Developmental Neurobiology
(Jacobson, 1970), a landmark book that critically summarized the
status of the core topics in the emerging field that thereafter
became known as developmental neurobiology. In two subse-
quent editions of this leading reference text (published by
Plenum Press in 1977 and 1991), Jacobson enlarged the book
substantially to maintain comprehensive coverage of a field that
was growing rapidly. Throughout his career, Jacobson showed a
strong interest in the history of neuroscience and embryology.
His deep understanding of the history of the field was integral to
all of his scientific publications but became more explicit and
extensive in the third edition of
Developmental Neurobiology
and
in his
Foundations of Neuroscience
(Jacobson, 1993), a consid-
eration of historical, epistemological and ethical aspects of neu-
roscience research.
Jacobson was a man of formidable energy and intellect
who was adept at provoking his colleagues to think deeply about
the ideas underlying their work. Although he readily adopted new
methods into his own research program, he warned against a pre-
occupation with techniques and observations at the expense of
hypotheses and models (Jacobson, 1993). Jacobson was a con-
noisseur and collector of Chinese art and he amassed an impor-
tant collection of modern Chinese paintings that, along with his
large collection of rare books on the history of embryology and
neuroscience, has been donated to the University of Utah. He is
survived by his wife and three adult children.
REFERENCES
Hunt, R.K. and Jacobson, M., 1974, Neuronal specificity revisited,
Curr. Top.
Dev. Biol.
8:203–259.
Jacobson, M., 1985, Clonal analysis and cell lineages of the vertebrate cen-
tral nervous system,
Ann. Rev. Neurosci.
8:71–102.
Jacobson, M., 1970,
Developmental Neurobiology
, Holt Rinehart & Winston,
New York.
Jacobson, M., 1993,
Foundations of Neuroscience
, Plenum Press, New York.
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